We looked inside some of the tweets by @IDJClub and here's what we found interesting.
Inside 100 Tweets
Q8 What type of antibiotic duration study would you like to see next? Do you find this aspect settled or are more gains feasible? #IDJClub
Q6 What are your overarching thoughts? Does this provide value over just stopping at 7 days? Are there certain situations you might look to employ this strategy? #IDJClub
Conclusion: Shorter antibiotic duration (with or without CRP-guidance) was non-inferior to a fixed 14-day course. Agree or disagree? #IDJClub
Adverse events were uncommon without differences across the three groups. The most prominent being Clostridium difficile colitis. #IDJClub
@adolfo7777 @IDJClub Agreed. I'm really glad they delineated this though because one of my big questions was going to be about resistance rates in Swis vs US. At least now I know it's mostly applicable for non-ESBLs. #IDJClub.
A few different people have made this point... but MDR doesn't generally mean increase in virulence or severity, all other factors being equal, should we treat them differently? #IDJClub https://t.co/QTodWA8Y03
Supplemental Table 3, Deviations from protocol (typically shorter or longer antibiotic courses depending on physician judgement) occurred in 34 of 164 patients (21%) in the CRP–guided group, 25 of 166 (15%) in the 7-day group, and 20 of 163 (12%) in the 14-day group. #IDJClub https://t.co/HUxlhfxE0o
Risk factors for failure after multivariable analysis: foreign body material and pulmonary origin, though none of the CRP patients with those features met the primary outcome. #IDJClub
There were numerical differences in the primary outcome event rate at 30 days across groups: CRP (2.4%), 7-day (6.6%), 14-day (5.5%). A worst case sensitivity analysis with missing data did not change meeting non-inferiority criteria. #IDJClub
Q4: Are you more hesitant to stop at 7 days for non-urinary sources of infection? What risk factors cause hesitation? #IDJClub